قالب:PBB/6622

Synuclein, alpha (non A4 component of amyloid precursor)
التراكيب المتوفرة
بنك بيانات البروتين	بحث أورثولوغ: PDBe, RCSB
قائمة رموز معرفات بنك بيانات البروتين
	1XQ8, 2JN5, 2KKW, 2M55, 2X6M, 3Q25, 3Q26, 3Q27, 3Q28, 3Q29, 4BXL, 4R0U, 4R0W
المعرفات
الرمز، (أو الرموز)	SNCA; NACP; PARK1; PARK4; PD1
معرفات خارجية	OMIM: 163890 MGI: 1277151 هومولوجين: 293 مختبر علم الأحياء الجزيئي الأوروبي الكيميائي: 6152 بطاقات الجينات: SNCA Gene
علم الوجود الجيني
الوظيفة الجزيئية	• magnesium ion binding; • fatty acid binding; • copper ion binding; • calcium ion binding; • protein binding; • phospholipid binding; • microtubule binding; • ferrous iron binding; • zinc ion binding; • oxidoreductase activity; • kinesin binding; • protein domain specific binding; • histone binding; • identical protein binding; • alpha-tubulin binding; • cysteine-type endopeptidase inhibitor activity involved in apoptotic process; • phospholipase binding; • transcription regulatory region DNA binding; • dynein binding; • protein N-terminus binding; • tau protein binding; • beta-tubulin binding; • phosphoprotein binding; • phospholipase D inhibitor activity;
المكونات الخلوية	• extracellular region; • extracellular space; • nucleus; • nuclear outer membrane; • cytoplasm; • mitochondrion; • mitochondrial respiratory chain complex I; • lysosome; • rough endoplasmic reticulum; • Golgi apparatus; • cytosol; • ribosome; • plasma membrane; • cell cortex; • synaptic vesicle; • actin cytoskeleton; • membrane; • inclusion body; • cell junction; • axon; • growth cone; • platelet alpha granule membrane; • terminal bouton; • fibril; • perinuclear region of cytoplasm;
العملية الإحيائية	• negative regulation of transcription from RNA polymerase II promoter; • microglial cell activation; • positive regulation of receptor recycling; • negative regulation of protein phosphorylation; • positive regulation of neurotransmitter secretion; • fatty acid metabolic process; • neutral lipid metabolic process; • phospholipid metabolic process; • activation of cysteine-type endopeptidase activity involved in apoptotic process; • mitochondrial membrane organization; • aging; • adult locomotory behavior; • response to iron(II) ion; • regulation of phospholipase activity; • negative regulation of platelet-derived growth factor receptor signaling pathway; • regulation of glutamate secretion; • regulation of dopamine secretion; • negative regulation of microtubule polymerization; • receptor internalization; • protein destabilization; • response to magnesium ion; • negative regulation of transporter activity; • response to lipopolysaccharide; • negative regulation of monooxygenase activity; • positive regulation of peptidyl-serine phosphorylation; • response to interferon-gamma; • cellular response to oxidative stress; • negative regulation of histone acetylation; • regulation of locomotion; • dopamine biosynthetic process; • response to drug; • mitochondrial ATP synthesis coupled electron transport; • regulation of macrophage activation; • positive regulation of apoptotic process; • negative regulation of apoptotic process; • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; • extracellular fibril organization; • negative regulation of neuron apoptotic process; • cellular response to fibroblast growth factor stimulus; • positive regulation of endocytosis; • negative regulation of exocytosis; • negative regulation of dopamine metabolic process; • behavioral response to cocaine; • regulation of long-term neuronal synaptic plasticity; • synaptic vesicle endocytosis; • synapse organization; • regulation of acyl-CoA biosynthetic process; • positive regulation of release of sequestered calcium ion into cytosol; • dopamine uptake involved in synaptic transmission; • negative regulation of dopamine uptake involved in synaptic transmission; • negative regulation of serotonin uptake; • negative regulation of norepinephrine uptake; • calcium ion homeostasis; • oxidation-reduction process; • regulation of excitatory postsynaptic membrane potential; • long-term synaptic potentiation; • positive regulation of inositol phosphate biosynthetic process; • negative regulation of thrombin receptor signaling pathway; • response to interleukin-1; • cellular response to copper ion; • cellular response to epinephrine stimulus; • positive regulation of protein serine/threonine kinase activity; • negative regulation of mitochondrial electron transport, NADH to ubiquinone; • positive regulation of glutathione peroxidase activity; • positive regulation of hydrogen peroxide catabolic process; • regulation of synaptic vesicle recycling; • regulation of reactive oxygen species biosynthetic process;
	المصادر: Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	مصادر أخرى عن بيانات أنماط التعبير
التقويمات
	ع; ن; ت;

^ Ulmer TS، Bax A، Cole NB، Nussbaum RL (مارس 2005). "Structure and dynamics of micelle-bound human alpha-synuclein". The Journal of Biological Chemistry. ج. 280 ع. 10: 9595–603. DOI:10.1074/jbc.M411805200. PMID:15615727.

[1] Ulmer TS، Bax A، Cole NB، Nussbaum RL (مارس 2005). "Structure and dynamics of micelle-bound human alpha-synuclein". The Journal of Biological Chemistry. ج. 280 ع. 10: 9595–603. DOI:10.1074/jbc.M411805200. PMID:15615727.

قالب:PBB/6622

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