English: Illustration of important relationships between metabolome, proteome, and genome in cancerous cells. Glycolysis breaks down glucose into pyruvate, which is then fermented to lactate; pyruvate flux through the tricarboxylic acid (TCA) cycle is down-regulated in cancer cells. Pathways branching off of glycolysis, such as the pentose phosphate pathway (PPP), generate biochemical building blocks to sustain the high proliferative rate of cancer cells. Specific genetic and enzyme-level behaviors are described in the main text. Blue boxes are enzymes important in transitioning to a cancer metabolic phenotype; orange boxes are enzymes that are mutated in cancer cells. Green ovals are oncogenes that are up-regulated in cancer; red ovals are tumor suppressors that are down-regulated in cancer. Figure abbreviations: 2PG: 2-phosphoglycerate; 3PG: 3-phosphoglycerate; BPG: 1,3-bisphosphoglycerate; CoA: coenzyme A; DHAP: dihydroxyacetone phosphate; F6P: fructose-6-phosphate; FBP: fructose-1,6-bisphosphate; G3P: glyceraldehyde-3-phospate; G6P: glucose-6-phosphate; HK: hexokinase; LDHA: lactate dehydrogenase A; PFK: phosphofructokinase; PI3K: phosphatidylinositide 3-kinase