جزيئات التصاق الخلايا العصبونية

An Error has occured retrieving Wikidata item for infobox جزيئات التصاق الخلايا العصبونية أو NRCAM‏ (Neuronal cell adhesion molecule) هوَ بروتين يُشَفر بواسطة جين NRCAM في الإنسان.^[1]^[2]^[3]

الوظيفة

الأهمية السريرية

المراجع

^ Lane RP، Chen XN، Yamakawa K، Vielmetter J، Korenberg JR، Dreyer WJ (ديسمبر 1996). "Characterization of a highly conserved human homolog to the chicken neural cell surface protein Bravo/Nr-CAM that maps to chromosome band 7q31". Genomics. ج. 35 ع. 3: 456–65. DOI:10.1006/geno.1996.0385. PMID:8812479.
^ "Entrez Gene: NRCAM neuronal cell adhesion molecule". مؤرشف من الأصل في 2010-12-05.
^ Marui T، Funatogawa I، Koishi S، وآخرون (2008). "Association of the neuronal cell adhesion molecule (NRCAM) gene variants with autism". Int J Neuropsychopharmacol. ج. 12 ع. 1: 1–10. DOI:10.1017/S1461145708009127. PMID:18664314.

قراءة متعمقة

Grumet M (1997). "Nr-CAM: a cell adhesion molecule with ligand and receptor functions". Cell Tissue Res. ج. 290 ع. 2: 423–8. DOI:10.1007/s004410050949. PMID:9321706.
Sakurai T، Lustig M، Nativ M، وآخرون (1997). "Induction of neurite outgrowth through contactin and Nr-CAM by extracellular regions of glial receptor tyrosine phosphatase beta". J. Cell Biol. ج. 136 ع. 4: 907–18. DOI:10.1083/jcb.136.4.907. PMC:2132488. PMID:9049255.
Nagase T، Ishikawa K، Nakajima D، وآخرون (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. ج. 4 ع. 2: 141–50. DOI:10.1093/dnares/4.2.141. PMID:9205841.
Wang B، Williams H، Du JS، وآخرون (1998). "Alternative splicing of human NrCAM in neural and nonneural tissues". Mol. Cell. Neurosci. ج. 10 ع. 5–6: 287–95. DOI:10.1006/mcne.1997.0658. PMID:9604207.
Moré MI، Kirsch FP، Rathjen FG (2001). "Targeted ablation of NrCAM or ankyrin-B results in disorganized lens fibers leading to cataract formation". J. Cell Biol. ج. 154 ع. 1: 187–96. DOI:10.1083/jcb.200104038. PMC:2196853. PMID:11449000.
Dry K، Kenwrick S، Rosenthal A، Platzer M (2001). "The complete sequence of the human locus for NgCAM-related cell adhesion molecule reveals a novel alternative exon in chick and man and conserved genomic organization for the L1 subfamily". Gene. ج. 273 ع. 1: 115–22. DOI:10.1016/S0378-1119(01)00493-0. PMID:11483367.
Jenkins SM، Bennett V (2002). "Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments". J. Cell Biol. ج. 155 ع. 5: 739–46. DOI:10.1083/jcb.200109026. PMC:2150881. PMID:11724816.
Aitkenhead M، Wang SJ، Nakatsu MN، وآخرون (2002). "Identification of endothelial cell genes expressed in an in vitro model of angiogenesis: induction of ESM-1, (beta)ig-h3, and NrCAM". Microvasc. Res. ج. 63 ع. 2: 159–71. DOI:10.1006/mvre.2001.2380. PMID:11866539.
Pavlou O، Theodorakis K، Falk J، وآخرون (2002). "Analysis of interactions of the adhesion molecule TAG-1 and its domains with other immunoglobulin superfamily members". Mol. Cell. Neurosci. ج. 20 ع. 3: 367–81. DOI:10.1006/mcne.2002.1105. PMID:12139915.
Conacci-Sorrell ME، Ben-Yedidia T، Shtutman M، وآخرون (2002). "Nr-CAM is a target gene of the beta-catenin/LEF-1 pathway in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis". Genes Dev. ج. 16 ع. 16: 2058–72. DOI:10.1101/gad.227502. PMC:186445. PMID:12183361.
Nakayama M، Kikuno R، Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. ج. 12 ع. 11: 1773–84. DOI:10.1101/gr.406902. PMC:187542. PMID:12421765.
Strausberg RL، Feingold EA، Grouse LH، وآخرون (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. ج. 99 ع. 26: 16899–903. DOI:10.1073/pnas.242603899. PMC:139241. PMID:12477932.
Hillier LW، Fulton RS، Fulton LA، وآخرون (2003). "The DNA sequence of human chromosome 7". Nature. ج. 424 ع. 6945: 157–64. DOI:10.1038/nature01782. PMID:12853948.
Custer AW، Kazarinova-Noyes K، Sakurai T، وآخرون (2003). "The role of the ankyrin-binding protein NrCAM in node of Ranvier formation". J. Neurosci. ج. 23 ع. 31: 10032–9. PMID:14602817.
Ota T، Suzuki Y، Nishikawa T، وآخرون (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. ج. 36 ع. 1: 40–5. DOI:10.1038/ng1285. PMID:14702039.
Hutcheson HB، Olson LM، Bradford Y، وآخرون (2004). "Examination of NRCAM, LRRN3, KIAA0716, and LAMB1 as autism candidate genes". BMC Med. Genet. ج. 5: 12. DOI:10.1186/1471-2350-5-12. PMC:420465. PMID:15128462.
Bonora E، Lamb JA، Barnby G، وآخرون (2005). "Mutation screening and association analysis of six candidate genes for autism on chromosome 7q". Eur. J. Hum. Genet. ج. 13 ع. 2: 198–207. DOI:10.1038/sj.ejhg.5201315. PMID:15523497.
Ishiguro H، Liu QR، Gong JP، وآخرون (2006). "NrCAM in addiction vulnerability: positional cloning, drug-regulation, haplotype-specific expression, and altered drug reward in knockout mice". Neuropsychopharmacology. ج. 31 ع. 3: 572–84. DOI:10.1038/sj.npp.1300855. PMID:16123759.

هذه بذرة مقالة عن جين على كروموسوم 7 بحاجة للتوسيع. فضلًا شارك في تحريرها.

[1] Lane RP، Chen XN، Yamakawa K، Vielmetter J، Korenberg JR، Dreyer WJ (ديسمبر 1996). "Characterization of a highly conserved human homolog to the chicken neural cell surface protein Bravo/Nr-CAM that maps to chromosome band 7q31". Genomics. ج. 35 ع. 3: 456–65. DOI:10.1006/geno.1996.0385. PMID:8812479.

[2] "Entrez Gene: NRCAM neuronal cell adhesion molecule". مؤرشف من الأصل في 2010-12-05.

[3] Marui T، Funatogawa I، Koishi S، وآخرون (2008). "Association of the neuronal cell adhesion molecule (NRCAM) gene variants with autism". Int J Neuropsychopharmacol. ج. 12 ع. 1: 1–10. DOI:10.1017/S1461145708009127. PMID:18664314.

[1]

[2]

[3]